Allah, the Exalted, informs about the disbelievers who associate partners with their Lord, that they have taken gods besides Allah, so that these gods may be a source of honor and might for them. They think that these gods give them power and make them victorious. Then, Allah mentions that the matter is not as they claim, and it will not be as they hope. He says,

{Nay, but they will deny their worship of them,} on the Day of Judgement.

{and will become their adversaries.} This means that they will be foes in a state other than what they think about these gods. This is similar to Allah’s statement.

And who is more astray than one who calls upon, besides Allah, such as will not answer him till the Day of Resurrection, and who are (even) unaware of their calls to them? And when mankind are gathered, they will become their enemies and will deny their worshipping.

As-Suddi said,

“This means their worshipping of the idols.”
Allah said,

contrary to what they hoped for from these gods.

As-Suddi said,

{and will become their adversaries.} “They will be in severe opposition and argument.”

Ad-Dahhak said,

{and ivill become their adversaries.} “This means enemies.”